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File283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2015-052017-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

DocumentFinal report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.01
Location: BF-GMS
Title:
Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_28314.pdf
Abstract/Results: ABSTRACT:
Nutrition is a key determinant of health, wellbeing and aging. Recent evidences strongly suggest that nutritional amino acids (AAs) are important mediators of this fitness effect in multiple species, including humans. Accordingly, animals have developed behavioral strategies to ensure a proper balance of AA intake. We have for example shown that upon yeast (main dietary protein source of fruit flies) or AA deprivation Drosophila melanogaster increases the intake of yeast leading to a switch in feeding preference from sucrose to yeast. This change in feeding choice underlies the dietary basis for nutritional AA homeostasis and serves as a powerful paradigm to study nutrient choice and homeostasis.
We have identified a distinct class of Drosophila melanogaster gustatory receptor neurons (GRNs) required for intake of yeast. We show that gustatory receptor neurons of the proboscis act in parallel to mediate yeast feeding. While nutritional and reproductive states act in concert to drive yeast appetite, we find a separation of these state signals at the level of yeast GRNs, with amino acid but not mating state enhancing yeast GRN gain. Importantly, the sensitivity of sweet GRNs to sugar is not increased by protein deprivation, providing a potential basis for this nutrient-specific appetite. The emerging picture is that different internal states act at distinct levels of a specific gustatory processing circuit to elicit nutrient-specific appetites towards a complex, ecologically relevant protein source.
Furthermore, we have made important additional discoveries at the level of the impact of gut bacteria on the selection of nutrients and have developed a new approach using genome information for designing diets optimizing both aging and reproductive output.
We have therefore achieved the main goals of the project which aimed at identifying and characterizing circuits regulating nutrient homeostasis and exploring the impact of nutrients on lifespan with a special focus on amino acids.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, C.
Document type:
Final report
Keywords:
Nutrition / Diet / Circuits / Drosophila / Brain

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging

DocumentCommensal bacteria control food choice behavior and reproduction by buffering the effect of essential amino acids availability2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.02
Location: BF-GMS
Title:
Commensal bacteria control food choice behavior and reproduction by buffering the effect of essential amino acids availability
Publication year: 2017
URL:
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2000862
Abstract/Results: ABSTRACT:
Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food. Furthermore, commensal bacteria buffer the animal from the lack of dietary eAAs: both increased yeast appetite and decreased reproduction induced by eAA deprivation are rescued by the presence of commensals. Surprisingly, these effects do not seem to be due to changes in AA titers, suggesting that gut bacteria act through a different mechanism to change behavior and reproduction. Thus, eAAs and commensal bacteria are potent modulators of feeding decisions and reproductive output. This demonstrates how the interaction of specific nutrients with the microbiome can shape behavioral decisions and life history traits.
Accessibility: Document exists in file
Language:
eng
Author:
Leitão-Gonçalves, R.
Secondary author(s):
Francisco, A., Carvalho-Santos, Z., Fioreze, G., Anjos, M., Baltazar, C., Elias, A., Itskov, P. M., Piper, M. D., Ribeiro, C.
Document type:
Article
Reference:
Leitão-Gonçalves, R., Francisco, A. P., Carvalho-Santos, Z., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D., & Ribeiro, C. (2017). Commensal bacteria control food choice behavior and reproduction by buffering the effect of essential amino acids availability. PLoS Biology, 15(4): e2000862. doi: 10.1371/journal.pbio.2000862
2-year Impact Factor: 8.386|2018
Impact factor notes: Impact factor not available yet for 2019
Times cited: 51|2019-07-10
Indexed document: Yes
Quartile: Q1
Keywords: Nutrition / Drosophila

DocumentMatching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.03
Location: BF-GMS
Title:
Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan
Publication year: 2017
URL:
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30095-5?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413117300955%3Fshowall%3Dtrue
Abstract/Results: ABSTRACT:
Balancing the quantity and quality of dietary protein relative to other nutrients is a key determinant of evolutionary fitness. A theoretical framework for defining a balanced diet would both reduce the enormous workload to optimize diets empirically and represent a breakthrough toward tailoring diets to the needs of consumers. Here, we report a simple and powerful in silico technique that uses the genome information of an organism to define its dietary amino acid requirements. We show for the fruit fly Drosophila melanogaster that such “exome-matched” diets are more satiating, enhance growth, and increase reproduction relative to non-matched diets. Thus, early life fitness traits can be enhanced at low levels of dietary amino acids that do not impose a cost to lifespan. Exome matching also enhanced mouse growth, indicating that it can be applied to other organisms whose genome sequence is known.
Accessibility: Document exists in file
Language:
eng
Author:
Piper, M. D.
Secondary author(s):
Soultoukis, G., Blanc, E., Mesaros, A., Herbert, S., He, X., Juricic, P., Salmonowicz, H., Yang, M., Simpson, S. J., Ribeiro, C., Partridge, L.
Document type:
Article
Reference:
Piper, M. D. W., Soultoukis, G. A., Blanc, E., Mesaros, A., Herbert, S. L., He, X., Juricic, P., Salmonowicz, H., Yang, M., Simpson, S. J., Ribeiro, C., & Partridge, L. (2017). Exome matching: a novel in silico approach to optimise dietary amino acid balance for growth and reproduction. Cell Metabolism, 25(3), 610-621. doi: 10.1016/j.cmet.2017.02.005
2-year Impact Factor: 22.415|2018
Impact factor notes: Impact factor not available yet for 2019
Times cited: 25|2019-07-10
Indexed document: Yes
Quartile: Q1
Keywords: Nutrition / Diet

Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan

Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan

DocumentGonadal ecdysone titers are modulated by protein availability but do not impact protein appetite2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.04
Location: BF-GMS
Title:
Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite
Publication year: 2018
URL:
http://www.sciencedirect.com/science/article/pii/S0022191017301130?via%3Dihub
Abstract/Results: ABSTRACT:
How animals survey internal nutrient availability to modulate specific appetites is currently largely unknown. Dietary proteins have a profound impact on the reproductive capacity and the selection of food sources in insects. When deprived of dietary proteins, insects stop producing eggs and develop strong protein appetites. In many adult insects, the ovaries are the site of synthesis of the ecdysone hormone. Therefore, an attractive hypothesis is that protein availability changes the gonadal production of ecdysone, which instructs the brain to increase its preference for yeast. We combine quantitative feeding assays, dietary manipulations, hormonal measurements, and genetic germline manipulations to test this hypothesis in Drosophila melanogaster. Our results show that upon yeast deprivation mated adult female Drosophila develop a strong yeast appetite and strongly reduce their egg production. This dietary manipulation also leads to a drastic reduction in ecdysone titers. However, the drop in ecdysone is not linked to the increase in yeast appetite as mutants with impaired oogenesis are able to adapt yeast intake to their nutrient state while displaying a constitutive low ecdysone titer. Interestingly, a low ecdysone titer is correlated with a lower level of overall food intake. Our data therefore show that in mated females the level of ecdysone reflects the level of protein in the diet and the physiological state of the ovaries. While the ovaries and ecdysone are unlikely to instruct the brain to develop a yeast appetite upon protein deprivation, they seem to be able to control overall food intake.
Accessibility: Document does not exist in file
Language:
eng
Author:
Carvalho-Santos, Z.
Secondary author(s):
Ribeiro, C.
Document type:
Article
Reference:
Carvalho-Santos, Z., & Ribero, C. (2018). Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite. Journal of Insect Physiology, 106, 30-35. doi: 10.1016/j.jinsphys.2017.08.006
2-year Impact Factor: 2.862|2018
Impact factor notes: Impact factor not available yet for 2020
Times cited: 2|2019-07-10
Indexed document: Yes
Quartile: Q1
Keywords: Ecdysone / Feeding behavior / Gonads / Drosophila melanogaster / Nutrient homeostasis / Protein appetite

DocumentThe gustatory basis of protein homeostasis2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.04
Location: BF-GMS
Title:
The gustatory basis of protein homeostasis
Publication year: 2017
URL:
http://www.genetics-gsa.org/drosophila/2017/pdf/Full%20Abstracts%20(including%20late).pdf
Abstract/Results: ABSTRACT:
Animals must adapt their behaviour to multiple ongoing internal states. In Drosophila, nutrient-specific hungers such as protein and salt appetite are driven by metabolic and reproductive states, but the neuronal mechanisms processing and integrating these states are unknown. Furthermore, despite its status as a key component of the fly’s diet, the sensory neurons that mediate feeding on yeast are unknown. Here, we employ a novel technology, the flyPAD, to dissect distinct aspects of feeding behaviour, and a chemically defined diet to differentiate the effects of different dietary components on feeding microstructure. Using these tools, we show that different internal states affect specific aspects of feeding on yeast, flies’ main source of dietary protein, to support protein homeostasis. Furthermore, we identify a distinct class of gustatory receptor neurons (GRNs) that are necessary for yeast feeding, and show that GRNs within this class in different anatomical locations mediate these different components of yeast feeding behaviour. Specifically, while GRNs on the labellum appear to be important for the initiation of feeding bursts, specific GRNs in the pharynx are necessary for sustaining yeast feeding bursts. We further identify a class of second-order gustatory neurons that regulate the sustaining of yeast feeding bursts according to the fly’s metabolic state. To characterise the response properties of GRNs, we employ 2-photon calcium imaging, and show that specific labellar GRNs respond selectively to yeast. This response is modulated by the flies’ dietary pretreatment: food high in yeast reduces the gain of taste peg GRNs, and this response correlates with changes in the probability of feeding burst initiation. Furthermore, female reproductive state is a key modulator of protein appetite. While mating strongly affects feeding burst initiation, it has no effect on the response of yeast GRNs, indicating that this internal state acts on higher-level gustatory circuits. The emerging picture is that specific yeast-sensing neurons mediate distinct aspects of feeding microstructure on a single substrate, but act redundantly to support total intake; and, further, that distinct internal states act at different levels of sensory processing to shape nutrient-specific hungers.
Accessibility: Document exists in file
Language:
eng
Author:
Walker, S.
Secondary author(s):
Steck, K., Itskov, P. M., Baltazar, C., Ribeiro, C.
Document type:
Online abstract
Reference:
Walker, S., Steck, K., Itskov, P. M., Baltazar, C., & Ribeiro, C. (2017, March). The gustatory basis of protein homeostasis. Paper presented at the 58th Annual Drosophila Research Conference, San Diego, USA. Abstract retreived from http://www.genetics-gsa.org/drosophila/2017/pdf/Full%20Abstracts%20(including%20late).pdf
Indexed document: No

The gustatory basis of protein homeostasis

The gustatory basis of protein homeostasis

DocumentThe gourmet fly - matching feeding decisions to the internal state of the animal2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.05
Location: BF-GMS
Title:
The gourmet fly - matching feeding decisions to the internal state of the animal
Publication year: 2015
URL:
http://www.ice.mpg.de/esito/pdf/ESITO_Abstracts_2015.pdf
Abstract/Results: ABSTRACT:
Nutrition is a key determinant of health, wellbeing and aging. To optimize survival and reproduction, animals must match their nutrient intake to their current needs. Many factors, including reproduction, profoundly change nutritional requirements, with many species showing an appetite for specific nutrients during specific periods of their lifecycle. How different internal states modify neuronal information processing to ensure homeostasis is poorly understood. I will discuss different circuit and molecular mechanisms used by the Drosophila brain to read out internal state information allowing the animals to appropriately select among different nutrients such as carbohydrates, amino acids and salt. A general theme emerging from our work is that internal states modify chemosensory processing using a combination of feed-forward and feed-back mechanisms leading to changes in the microstructure of feeding and hence feeding decisions. Importantly, these changes are adaptive as they allow the animal to optimize its reproductive output over its lifetime. Changes in chemosensory processing and feeding microstructure may represent common mechanisms through which internal state-sensitive circuits modify feeding decisions across species.
Accessibility: Document exists in file
Language:
eng
Author:
Walker, S.
Secondary author(s):
Leitão-Gonçalves, R., Francisco, A., Herbert, S., Corrales-Carvajal, V., Carvalho-Santos, Z., Itskov, P. M., Fioreze, G., Elias, A., Piper, M. D., Ribeiro, C.
Document type:
Abstract book
Reference:
Walker, S., Leitão-Gonçalves, R., Francisco, A., Herbert, S., Corrales-Carvajal, V., Carvalho-Santos, Z., Itskov, P. M., Fioreze, G., Elias, A., Piper, M. D., & Ribeiro, C. (2015). The gourmet fly - matching feeding decisions to the internal state of the animal. Paper presented at the XIV European Symposium for Insect Taste and Olfaction (ESITO) (p. 8). Villasimius, Italy.
Indexed document: No

The gourmet fly - matching feeding decisions to the internal state of the animal

The gourmet fly - matching feeding decisions to the internal state of the animal

DocumentIdentification of sensory neurons and receptors that mediate yeast and amino acid feeding in Drosophila melanogaster2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Notes:
Author: Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.06
Location: BF-GMS
Title:
Identification of sensory neurons and receptors that mediate yeast and amino acid feeding in Drosophila melanogaster
Publication year: 2015
URL:
http://www.ice.mpg.de/esito/pdf/ESITO_Abstracts_2015.pdf
Abstract/Results: ABSTRACT:
In most animals olfaction and taste play a major role in the selection of the appropriate food sources needed to satisfy their metabolic requirements. These requirements vary a lot depending on the current needs of the animal. The molecular and neuronal mechanisms the brain uses to detect these specific metabolic requirements and modify the chemosensory input to prioritize among the different available feeding possibilities are currently largely unknown. Despite being key nutrients the identity of the chemosensory channels insects use to decide to ingest amino acid rich food remains to be identified. This is also the case in Drosophila melanogaster where the chemosensory basis for the ingestion of yeast, its main source of amino acids, or pure amino acids remains elusive. We used a combination of two choice feeding assays, internal state manipulations, neuronal silencing approaches and neuroanatomy to identify a subset of chemosensory neurons that is required for ingestion of yeast and amino acid rich food. The identified neurons are part of the gustatory system and label the taste pegs of the labellum and the internal sense organs of the cibarium. We are currently aiming at characterizing the function of the identified neurons using calcium imaging and identifying the receptor genes mediating amino acid feeding. This work thus provides important novel insights into the chemosensory basis of amino acid feeding, one of the elementary gustatory modalities promoting the fitness of the animal.
Accessibility: Document exists in file
Language:
eng
Author:
Steck, K.
Secondary author(s):
Baltazar, C., Elias, A. P., Fioreze, G., Itskov, P. M., Leitão-Gonçalves, R., Ribeiro, C.
Document type:
Abstract book
Reference:
Steck, K., Baltazar, C., Elias, A. P., Fioreze, G., Itskov, P. M., Leitão-Gonçalves, R., & Ribeiro, C. (2015). Identification of sensory neurons and receptors that mediate yeast and amino acid feeding in Drosophila melanogaster. Paper presented at the XIV European Symposium for Insect Taste and Olfaction (ESITO) (p. 23). Villasimius, Italy.
Indexed document: No

Identification of sensory neurons and receptors that mediate yeast and amino acid feeding in Drosophila melanogaster

Identification of sensory neurons and receptors that mediate yeast and amino acid feeding in Drosophila melanogaster