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File253 - The impact of lipid signaling modulation in cognition2015-05

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-253
Location: BF-GMS
Title:
253 - The impact of lipid signaling modulation in cognition
Duration: 2015-05
Researcher(s):
Tiago Gil Rodrigues Oliveira, Isabel Maria Sousa Castanho, Neide Marina Vieira Pereira, Rita Catarina Ribeiro da Silva, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project is still in progress
Author: Oliveira, T. G.
Secondary author(s):
Castanho, I., Pereira, N., Silva, R., Pinto, V.
Keywords:
Lipids / Hippocampus / Cognition / Memory / Psychophysiology

DocumentFinal report - The impact of lipid signaling modulation in cognition2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-253
Location: BF-GMS
Title:
253 - The impact of lipid signaling modulation in cognition
Duration: 2015-05
Researcher(s):
Tiago Gil Rodrigues Oliveira, Isabel Maria Sousa Castanho, Neide Marina Vieira Pereira, Rita Catarina Ribeiro da Silva, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project is still in progress
Author: Oliveira, T. G.
Secondary author(s):
Castanho, I., Pereira, N., Silva, R., Pinto, V.
Keywords:
Lipids / Hippocampus / Cognition / Memory / Psychophysiology

Reference code: PT/FB/BL-2014-253.01
Title: Final report - The impact of lipid signaling modulation in cognition
Publication year: 2018
Abstract/Results:
ABSTRACT:
Over the past years increasing amount of attention has been given to signaling lipids as well as to its modulating enzymes, such as phospholipases. Specifically, phospholipase D (PLD), that converts phosphatidylcholine to phosphatidic acid (PA), has been shown to exhibit a role in neurological development and physiology. Several studies have been associating PLD1 and PLD2, the two main mammalian PLD isozymes, to neurological processes, including neurotransmitter release, dendritic branching, cognition, and brain development. Also, the hippocampus has been suggested as one of the brain regions showing the highest PLD activity and neurodegenerative conditions such as Alzheimer’s disease associated pathways have been shown to be modulated by PLD signaling. Thus, the aim of this project was to better understand the potential role of PLD in hippocampal function in adult mice upon Pld1 or Pld2 genetic ablation.
We performed a hippocampal related behavioral characterization of these animals, a structural analysis regarding dendritic morphology, electrophysiology neuronal plasticity evaluation and protein and lipidomic biochemical detailed analysis.
Our behavioral data, specifically considering motor and exploratory activity, anxiety and memory, showed that PLD2 knockout mice behavior is not altered when compared to their wild type littermates. Although most of this was also observed in the animals lacking PLD1, the results indicate an object recognition-dependent short-term memory deficit. Regarding hippocampal dendritic arborization, the ablation of either PLD1 or PLD2 led to significant alterations in dendritic morphology, although with a different impact of each isozyme in the dorsal and ventral hippocampus. Concerning the electrophysiological plasticity analysis we observed a deficit in long-term depression in the dorsal hippocampus of PLD1 knock-out mice. Finally our biochemical analysis revealed a significant decrease in SNAP-25 protein levels and total levels of PA levels in PLD1 knock-out mice while no major changes were observed upon PLD2 genetic ablation.
Our results suggest that the separate ablation of PLD1 and PLD2 leads to different effects in the dorsal and ventral hippocampus, with a more significant effect upon PLD1 ablation.
Accessibility: Document exists in file
Language:
eng
Author:
Oliveira, T. G.
Document type:
Final report
Reference:
Oliveira, T. G. (2018). Final report - The impact of lipid signaling modulation in cognition.
Keywords: Cognition / Lipids / Memory / Learning / Hippocampus / Phospholipase D.

Final report - The impact of lipid signaling modulation in cognition

Final report - The impact of lipid signaling modulation in cognition

DocumentThe impact of phospholipase d2 genetic ablation in adult mouse hippocampal synaptic functioning2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-253
Location: BF-GMS
Title:
253 - The impact of lipid signaling modulation in cognition
Duration: 2015-05
Researcher(s):
Tiago Gil Rodrigues Oliveira, Isabel Maria Sousa Castanho, Neide Marina Vieira Pereira, Rita Catarina Ribeiro da Silva, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project is still in progress
Author: Oliveira, T. G.
Secondary author(s):
Castanho, I., Pereira, N., Silva, R., Pinto, V.
Keywords:
Lipids / Hippocampus / Cognition / Memory / Psychophysiology

Reference code: PT/FB/BL-2014-253.02
Location: BF-GMS
Title:
The impact of phospholipase d2 genetic ablation in adult mouse hippocampal synaptic functioning
Publication year: 2016
URL:
http://www.isnplaza.org/isn/program_and_abstractbook/ISN2016/PDF-Versions/ISN%202016%20Program%20&%20Abstract%20Book.pdf
Abstract/Results: ABSTRACT:
Lipids are a major constituent of the brain and lipid metabolic defects have been implicated in neurodegenerative diseases.
Phospholipase D (PLD) is a lipid-modulating enzyme and, in mammals, there are two main PLD isozymes - PLD1 and PLD2, which generate phosphatidic acid from phosphatidylcholine, affecting signaling lipid and membrane trafficking processes. The hippocampus has been suggested as one of the brain regions showing the highest PLD activity and at the pathological level, PLD was shown to play a role in Alzheimer’s disease (AD) pathogenesis. Also, it was recently shown that the hippocampus presents different electrophysiological properties with differential functions along its longitudinal axis. While the dorsal hippocampus (DH) is predominantly involved in spatial navigation and episodic memory, the ventral hippocampus (VH) is more involved in emotional related behaviors. Since synaptic hippocampal plasticity is fundamental in learning processes and since it was shown to be impaired in the setting of AD, we propose to study the impact of PLD2 ablation in adult hippocampal synaptic functioning along its dorso-ventral axis. Dorsal hippocampus (DH) and ventral hippocampus (VH) slices were prepared from PLD2 wild-type (WT) and PLD2 knock-out (KO) and used for extracellular recordings. In the input-output relationship and paired-pulse facilitation ratio, PLD2 ablation had no significant impact. In long-term depression (LTD) inducibility, while we found no changes upon PLD2 ablation
in the DH, in the VH we observed an increased excitability in the early LTD induction phase in PLD2 KO animals. In summary, we show that PLD2 ablation does not affect hippocampal plasticity properties in the DH and that it leads to earlyphase LTD induction deficit in the VH. Future studies addressing the molecular associated pathways in early-phase LTD will shed light in PLD2-dependent mechanisms.
Accessibility: Document exists in file
Language:
eng
Author:
Santa-Marinha, L.
Secondary author(s):
Bravo, F. V., Di Paolo, G., Pinto, V., Oliveira, T. G.
Document type:
Conference abstract
Reference:
Santa-Marinha, L., Bravo, F. V., Di Paolo, G., Pinto, V., Oliveira, T. G. (2016). The impact of phospholipase D2 genetic ablation in adult mouse hippocampal synaptic functioning. Program Book of the the 7th ISN Special Neurochemistry Conference on Synaptic function and Dysfunction in Brain Diseases (pp. 41-42). Coimbra, Portugal.
Indexed document: No
Keywords: Lipids

The impact of phospholipase d2 genetic ablation in adult mouse hippocampal synaptic functioning

The impact of phospholipase d2 genetic ablation in adult mouse hippocampal synaptic functioning

DocumentDifferential lipid composition and regulation along the hippocampal longitudinal axis2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-253
Location: BF-GMS
Title:
253 - The impact of lipid signaling modulation in cognition
Duration: 2015-05
Researcher(s):
Tiago Gil Rodrigues Oliveira, Isabel Maria Sousa Castanho, Neide Marina Vieira Pereira, Rita Catarina Ribeiro da Silva, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project is still in progress
Author: Oliveira, T. G.
Secondary author(s):
Castanho, I., Pereira, N., Silva, R., Pinto, V.
Keywords:
Lipids / Hippocampus / Cognition / Memory / Psychophysiology

Reference code: PT/FB/BL-2014-253.03
Location: BF-GMS
Title:
Differential lipid composition and regulation along the hippocampal longitudinal axis
Publication year: 2019
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486574/
Abstract/Results: ABSTRACT
Lipids are major constituents of the brain largely implicated in physiological and pathological processes. The hippocampus is a complex brain structure involved in learning, memory and emotional responses, and its functioning is also affected in various disorders. Despite conserved intrinsic circuitry, behavioral and anatomical studies suggest the existence of a structural and functional gradient along the hippocampal longitudinal axis. Here, we used an unbiased mass spectrometry approach to characterize the lipid composition of distinct hippocampal subregions. In addition, we evaluated the susceptibility of each area to lipid modulation by corticosterone (CORT), an important mediator of the effects of stress. We confirmed a great similarity between hippocampal subregions relatively to other brain areas. Moreover, we observed a continuous molecular gradient along the longitudinal axis of the hippocampus, with the dorsal and ventral extremities differing significantly from each other, particularly in the relative abundance of sphingolipids and phospholipids. Also, whereas chronic CORT exposure led to remodeling of triacylglycerol and phosphatidylinositol species in both hippocampal poles, our study suggests that the ventral hippocampus is more sensitive to CORT-induced changes, with regional modulation of ceramide, dihydrosphingomyelin and phosphatidic acid. Thus, our results confirm a multipartite molecular view of dorsal-ventral hippocampal axis and emphasize lipid metabolites as candidate effectors of glucocorticoid signaling, mediating regional susceptibility to neurological disorders associated with stress.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Miranda, A. M.
Secondary author(s):
Bravo, F. V., Chan, R. B., Sousa, N., Di Paolo, G., Oliveira, T. G.
Document type:
Article
Reference:
Miranda, A. M., Bravo, F. V., Chan, R. B., Sousa, N., Di Paolo, G., & Oliveira, T. G. (2019). Differential lipid composition and regulation along the hippocampal longitudinal axis. Translational Psychiatry, 9: 144. doi: 10.1038/s41398-019-0478-6
2-year Impact Factor: 5.182|2018
Impact factor notes: Impact factor not available yet for 2021
Times cited: 1|2019-07-11
Indexed document: Yes
Quartile: Q1
Keywords: Molecular neuroscience / Depression

Differential lipid composition and regulation along the hippocampal longitudinal axis

Differential lipid composition and regulation along the hippocampal longitudinal axis